The aim of the present study is to design and characterize an oral, pulsatile drug delivery system of Ivabradine HCl (IBH) intended to approximate the chronobiology of angina pectoris, proposed for colonic targeting. It is a chronopharmaceutical approach for the better treatment of angina pectoris. In this study, investigation of an oral colon specific, pulsatile device to achieve time or site specific release of IBH, based on chronopharmaceutical considerations. Bodies of hard gelatin capsules were treated with formaldehyde keeping the caps as such. Ivabradine HCl microspheres prepared by solvent evaporation method using eudragit L-100 and eudragit S-100 in the ratio 1:2 were incorporated into these specialized capsule shells and plugged with polymers guar gum and HPMC individually at concentrations 20 mg and 40 mg, to maintain a suitable lag period and it was found that the drug release was controlled by the proportion of polymers used. Finally the filled capsules were completely coated with cellulose acetate phthalate to prevent variable gastric emptying. Based on the concept that a formulation on leaving the stomach, arrives at the ileocaecal junction in about 5 to 6 hours after administration and difference in pH throughout GIT, a time and pH dependent pulsatile drug delivery system is designed. The results shows that significant drug release occur after 5 h from the start of experiment. Thus, we can conclude that IBH could be successfully colon targeted by the use of the modified Pulsincap, thereby reducing the systemic side effects.
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